Managing incidental genomic findings: legal obligations of clinicians
نویسندگان
چکیده
منابع مشابه
Defining and managing incidental findings in genetic and genomic practice.
The rapidly declining costs and increasing speeds of whole-genome analysis mean that genetic testing is undergoing a shift from targeted approaches to broader ones that look at the entire genome. As whole-genome technologies gain widespread use, questions about the management of so-called incidental findings-those unrelated to the question being asked-need urgent consideration. In this review, ...
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Recent work on incidental findings, concentrating on the difficult problems posed by the ambiguous results often generated by high-tech medicine, has proceeded largely independently from recent work on medical researchers' ancillary-care obligations, the obligations that researchers have to deal with diseases or conditions besides the one(s) under study. This paper contends that the two topics ...
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The Human Genome Project showed that there is significant genetic variation within the population. Current research is accumulating large databases that may reveal genetic variations associated with disease or health risks, even if not intended as part of the study design. These incidental findings create legal, ethical, and financial challenges for researchers. Current federal and internationa...
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1 Clinical Research Program, Pasqual Maragall Foundation, Barcelona, Spain, 2 Center for Human Disease Modeling, Department of Cell Biology, Department of Medicine, Duke University, Durham, North Carolina, United States of America, 3 Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, 4 Center for Bioethics and Health Law, University...
متن کاملFinding Fault? Exploring Legal Duties to Return Incidental Findings in Genomic Research.
The use of whole-genome sequencing in biomedical research is expected to produce dramatic advances in human health. The increasing use of this powerful, data-rich new technology in research, however, will inevitably give rise to incidental findings (IFs)-findings with individual health or reproductive significance that are beyond the aims of the particular research-and the related questions of ...
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ژورنال
عنوان ژورنال: Genetics in Medicine
سال: 2013
ISSN: 1098-3600,1530-0366
DOI: 10.1038/gim.2013.7